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We included cases with AD (panic disorder, agoraphobia, specific phobia, social phobia, obsessive-compulsive disorder, posttraumatic stress disorder, acute stress disorder, and generalized anxiety disorder) based on the ICD-9-CM codes 300.01, 300.02, 300.2, 300.20�C300.29, 300.3, 308, and 309.81�C309.83. In #links# this study, we only selected cases who had received an AD diagnoses within 3 years prior to the index date. All the AD cases included in this study were diagnosed by the certified psychiatrist. In Taiwan, the diagnosis of AD is made through the diagnostic interview, mental status examination, physical examination, and neurological examination in order to confirm the symptom profiles, illness duration, personal and social function. In addition, the diagnosis of AD has to exclude the organic etiology by the criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM) or International Classification of Diseases (ICD). This study used the SAS system (SAS System for Windows, vers. 8.2, SAS Institute, Cary, NC) to conduct all statistical analyses performed in this study. We used a conditional logistic regression (conditioned on the age group and index #links# year) to calculate the odds ratio (OR) for having been previously diagnosed with AD between cases and controls. In the regression model, we adjusted for medical co-morbidities including diabetes, hypertension, coronary #links# heart disease (CHD), obesity, hyperlipidemia, chronic pelvic pain (CPP), irritable bowel syndrome (IBS), fibromyalgia, chronic fatigue syndrome (CFS), depression, panic disorder, migraine, sicca syndrome, allergies, endometriosis, asthma, and overactive bladder (OAB). The conventional P?��?0.05 was used to assess the statistical significance. Of the 396 cases and 1,980 controls, the mean age was 47.5?��?15.1 years. Table I shows that there were no significant differences in the distribution of monthly income or geographic region between cases and controls. However, as to medical co-morbidities, cases had a higher prevalence than controls of CPP (40.2% vs. 21.2%, P?<?0.001), IBS (13.1% vs. 5.4%, P?<?0.001), fibromyalgia (32.8% vs. 22.3%, P?<?0.001), migraines (7.3% vs. 3.6%, P?<?0.001), sicca syndrome (3.3% vs. 1.3%, P?=?0.003), allergies (23.3% vs. 1.1%, P?<?0.001), asthma (9.9% vs. 6.5%, P?=?0.018), and OAB (4.2% vs. 1.6%; P?=?0.012). Table II shows that of the 2,376 sampled subjects, 136 (5.72%) had received an AD diagnosis before the index date. AD was found in 64 (16.16%) cases and 72 (3.64%) controls. The ��2-test showed that cases had a higher prevalence of AD than controls (P?<?0.001). Table III presents the covariate-adjusted ORs for previous AD. We only included medical co-morbidities which were significantly related to BPS/IC in the regression model.</p>